Clinical Presentation, Treatment and Outcome of Patients with Malignant Ureteric Obstruction in JUTH.

Abstract

Introduction: Malignant ureteric obstruction is usually associated with end stage cancer arising from the cervix, bladder, prostate and other pelvic organs. This study aims to assess the clinical presentation,treatment and outcome of patients with malignant ureteric obstruction in Jos University Teaching Hospital (JUTH). Methods: This is a retrospective cross-sectional study carried out in JUTH over a 10 year period (2010-2019). All patients managed or co- managed by the urology division of JUTH for ureteric obstruction of malignant cause were recruited for the study. Interventions carried out included open nephrostomy, ureteric stenting and dialysis. 40 patients were managed within this period but only 24 patients had complete record. Result: Cervical cancer is the most prevalent cause of malignant ureteric obstruction. About 60% of the patients had open nephrostomy which also offered the most significant improvement in biochemical outcome. None of the treatment options conferred survival advantage over the others. Conclusion: Open nephrostomy is the most common treatment option and achieves the most significant biochemical improvement. No treatment option confers superior survival outcome.